Upneeq

It will depend on the person, but the clinical trials for Upneeq showed that most patients saw the highest lift in their eyelids in as little as 2 hours and the average lift that patients experienced was 1 mm. One study showed that some patients saw a lift in their eyelids as soon as 5 to 15 minutes after their first dose.

How long the effect lasts will vary from patient to patient, but the clinical trials for Upneeq showed that the greatest lift was seen at 2 hours and the lid remained lifted for up to 8 hours.

In clinical trials, patients took Upneeq once a day for 6 weeks. And in these clinical trials, there was no evidence that the effect from oncedaily application of Upneeq decreased with continued use.

Upneeq is indicated for daily use in the affected eye(s) with acquired ptosis. In clinical trials, the effect lasted from 6 to 8 hours. Some patients choose to use Upneeq on select days when they would like to treat their droopy eyelids. However, to get results on a daily basis, Upneeq needs to be applied as a once-daily drop. Consult your healthcare provider if you have questions on using Upneeq.

Upneeq should be used once a day, 1 drop in each affected eye with acquired ptosis. There is no evidence to suggest that using it more often or using more than 1 drop will increase its effectiveness.

If you wear contact lenses, remove them before using Upneeq. You should wait at least 15 minutes before placing them back into your eyes. If you wear contact lenses and have questions about also using Upneeq, consult your eyecare professional.

If you are using Upneeq with other eye (ophthalmic) medicines, you should wait at least 15 minutes between using Upneeq and the other medicines. If you are using other eye drops and have questions about also using Upneeq, consult your eyecare professional.

No, you should not save any unused Upneeq. After you have applied the daily dose of medicine, throw away (dispose of) the single patient-use container and any unused Upneeq. Do not save any unused Upneeq. Do not let the tip of the Upneeq single patient-use container touch your eye or any other surfaces to avoid contamination or injury to your eye.

IMPORTANT SAFETY INFORMATION
What warnings and precautions are associated with UPNEEQ? (cont’d)

• UPNEEQ may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using UPNEEQ.
• Do not let the tip of the UPNEEQ vial touch your eye or any other surface. This can help prevent eye injury or contamination. Each UPNEEQ vial is for one-time use and should be discarded after being used. Please see full Important Safety Information on pages 6 and 7. Please see accompanying full Prescribing Information and Patient Information.

Please see accompanying full Prescribing Information and Patient Information.

Information. If you have heart disease, uncontrolled high or low blood pressure, feel faint at rest or when quickly standing up, you should call your doctor if your symptoms get worse.2 If you have any questions about whether Upneeq is right for you, consult your doctor.

In clinical trials, Upneeq was proven to be safe and effective when used as directed. The most common adverse reactions with Upneeq (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache. These are not all of the possible side effects of Upneeq. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects.

In clinical trials, the majority of patients who used Upneeq reported that it caused “no discomfort” (95.5% of patients who used Upneeq for 6 weeks and 92.0% of patients who used Upneeq for 12 weeks), and almost all (94.9%) of those included in the clinical trials completed all study visits, which indicated that they were comfortable enough to continue daily dosing.

See Patient Counseling Information and Instructions For Use in the accompanying full Prescribing Information.

No, there is no evidence from clinical trials that Upneeq affects eye color or skin pigmentation. The active ingredient of Upneeq, oxymetazoline, has been well studied and is known to primarily act on a muscle of the eyelid.

Prior to starting Upneeq, you should be aware of the following information. Upneeq may increase the risk of eye pressure due to fluid buildup (angle-closure glaucoma) in patients with untreated narrow-angle glaucoma. Call your doctor immediately if you feel increased pressure in your eye after using Upneeq. If you have any questions, you should consult your eye care professional.

If you are using Upneeq with other eye (ophthalmic) medicines, you should wait at least 15 minutes between using Upneeq and the other medicines.

Prior to starting Upneeq, you should be aware of the following

IMPORTANT SAFETY INFORMATION
What are the most common side effects of UPNEEQ?

The most common adverse reactions with UPNEEQ (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache.

Prior to starting Upneeq, you should be aware of the following information. The most common adverse reactions with Upneeq (occurring in 1-5% of patients) were eye inflammation, eye redness, dry eye, blurred vision, eye pain at time of use, eye irritation, and headache. These are not all of the possible side effects of Upneeq. Tell your doctor if you have any side effect that bothers you or does not go away. Call your doctor for medical advice about side effects. If you have any questions, you should consult your eye care professional.

If you have Sjogren’s syndrome, you should use care when taking Upneeq. Call your doctor immediately if you feel your symptoms may be getting worse. If you have any questions about whether Upneeq is right for you, consult your doctor.

Patients who have had cataract or LASIK surgery are not excluded from using Upneeq. You should consult with your eye care provider if you have questions about using Upneeq following cataract, LASIK, or any other eye surgery